diff --git a/src/Air.zig b/src/Air.zig
index e08993bbed..46ba297003 100644
--- a/src/Air.zig
+++ b/src/Air.zig
@@ -811,7 +811,7 @@ pub const Inst = struct {
         // bigger than expected. Note that in Debug builds, Zig is allowed
         // to insert a secret field for safety checks.
         comptime {
-            if (builtin.mode != .Debug) {
+            if (builtin.mode != .Debug and builtin.mode != .ReleaseSafe) {
                 assert(@sizeOf(Data) == 8);
             }
         }
diff --git a/src/Zir.zig b/src/Zir.zig
index 9621aefcf6..167a55d19e 100644
--- a/src/Zir.zig
+++ b/src/Zir.zig
@@ -2602,7 +2602,7 @@ pub const Inst = struct {
         // bigger than expected. Note that in Debug builds, Zig is allowed
         // to insert a secret field for safety checks.
         comptime {
-            if (builtin.mode != .Debug) {
+            if (builtin.mode != .Debug and builtin.mode != .ReleaseSafe) {
                 assert(@sizeOf(Data) == 8);
             }
         }
diff --git a/src/arch/aarch64/Mir.zig b/src/arch/aarch64/Mir.zig
index 00537e0e38..f6e3cebff5 100644
--- a/src/arch/aarch64/Mir.zig
+++ b/src/arch/aarch64/Mir.zig
@@ -473,7 +473,7 @@ pub const Inst = struct {
     // Make sure we don't accidentally make instructions bigger than expected.
     // Note that in Debug builds, Zig is allowed to insert a secret field for safety checks.
     comptime {
-        if (builtin.mode != .Debug) {
+        if (builtin.mode != .Debug and builtin.mode != .ReleaseSafe) {
             assert(@sizeOf(Data) == 8);
         }
     }
diff --git a/src/arch/arm/Mir.zig b/src/arch/arm/Mir.zig
index 38cf4da3fd..ab64dbf738 100644
--- a/src/arch/arm/Mir.zig
+++ b/src/arch/arm/Mir.zig
@@ -264,7 +264,7 @@ pub const Inst = struct {
     // Make sure we don't accidentally make instructions bigger than expected.
     // Note that in Debug builds, Zig is allowed to insert a secret field for safety checks.
     comptime {
-        if (builtin.mode != .Debug) {
+        if (builtin.mode != .Debug and builtin.mode != .ReleaseSafe) {
             assert(@sizeOf(Data) == 8);
         }
     }
diff --git a/src/arch/sparc64/Mir.zig b/src/arch/sparc64/Mir.zig
index 52dba34e56..a040af60c4 100644
--- a/src/arch/sparc64/Mir.zig
+++ b/src/arch/sparc64/Mir.zig
@@ -328,7 +328,7 @@ pub const Inst = struct {
     // Make sure we don't accidentally make instructions bigger than expected.
     // Note that in Debug builds, Zig is allowed to insert a secret field for safety checks.
     comptime {
-        if (builtin.mode != .Debug) {
+        if (builtin.mode != .Debug and builtin.mode != .ReleaseSafe) {
             assert(@sizeOf(Data) == 8);
         }
     }
diff --git a/src/arch/x86_64/Mir.zig b/src/arch/x86_64/Mir.zig
index 182f3267a6..5bd8dc68f6 100644
--- a/src/arch/x86_64/Mir.zig
+++ b/src/arch/x86_64/Mir.zig
@@ -462,7 +462,7 @@ pub const Inst = struct {
     // Make sure we don't accidentally make instructions bigger than expected.
     // Note that in Debug builds, Zig is allowed to insert a secret field for safety checks.
     comptime {
-        if (builtin.mode != .Debug) {
+        if (builtin.mode != .Debug and builtin.mode != .ReleaseSafe) {
             assert(@sizeOf(Data) == 8);
         }
     }